antigen processing and presentation
| PAG Title | antigen processing and presentation |
| PAG ID | WAG000024 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Invariant chain (Ii) associates with newly synthesized class II molecules in the endoplasmic reticulum (ER), an interaction that has been shown to interfere with peptide binding to class II molecules. The class II-associated invariant chain peptide (CLIP) region (residues 81- 104) of Ii is believed to mediate this inhibition by engaging the binding domain of class II like an antigenic peptide. Together, these findings have given rise to a model in which CLIP association with the class II groove acts to prevent ippropriate presentation of peptides imported into the ER for association with major histocompatibility complex class I molecules. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 329 |
| Information Content | Rich |
| Other IDs | |
| Base PAG ID | WAG000024 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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